Protein Kinases and Transcription Factors Activation in Response to UV-Radiation of Skin: Implications for Carcinogenesis
作者： César López-Camarillo , Elena Aréchaga Ocampo , Mavil López Casamichana , Carlos Pérez-Plasencia , Elizbeth Álvarez-Sánchez
DOI: 10.3390/IJMS13010142
关键词:
摘要: Solar ultraviolet (UV) radiation is an important environmental factor that leads to immune suppression, inflammation, photoaging, and skin carcinogenesis. Here, we reviewed the specific signal transduction pathways transcription factors involved in cellular response UV-irradiation. Increasing experimental data supporting a role for p38, MAPK, JNK, ERK1/2, ATM kinases network UV exposure discussed. We also participation of NF-κB, AP-1, NRF2 control gene expression after In addition, discussed promising chemotherapeutic intervention signaling by natural compounds. Finally, focused on review emerging from use DNA microarray technology determine changes global keratinocytes melanocytes treatment. Efforts obtain comprehensive portrait transcriptional events regulating photodamage intact human epidermis reveals existence novel participating UV-induced cell death. Progress understanding multitude mechanisms induced UV-irradiation could lead potential protein proteins as targets prevention cancer.
mdpi.com
sci-hub.se 参考文章(173)
Régnier M, Duval C, Schmidt R, Lagrange A, Philippe M, Tuloup R, Galey Jb, Keratinocyte-melanocyte co-cultures and pigmented reconstructed human epidermis: models to study modulation of melanogenesis. Cellular and Molecular Biology. ,vol. 45, pp. 969- ,(1999)
Frank R. de Gruijl, [33] Photocarcinogenesis: UVA vs UVB Methods in Enzymology. ,vol. 319, pp. 359- 366 ,(2000) , 10.1016/S0076-6879(00)19035-4
Nancy H. Colburn, Paritosh Ghosh, Jian-Jian Li, Chandra Westergaard, Inhibitors of both nuclear factor-κB and activator protein-1 activation block the neoplastic transformation response Cancer Research. ,vol. 57, pp. 3569- 3576 ,(1997)
Yukihito Kabuyama, Miwako K. Homma, Tomohiro Kurosaki, Yoshimi Homma, Early signaling events induced by 280-nm UV irradiation European Journal of Biochemistry. ,vol. 269, pp. 664- 670 ,(2002) , 10.1046/J.0014-2956.2001.02698.X
Julia Li Zhong, Li Yang, Fenglin Lü, Han Xiao, Ruoqi Xu, Lijuan Wang, Feng Zhu, Yiguo Zhang, UVA, UVB and UVC Induce Differential Response Signaling Pathways Converged on the eIF2α Phosphorylation Photochemistry and Photobiology. ,vol. 87, pp. 1092- 1104 ,(2011) , 10.1111/J.1751-1097.2011.00963.X
C. Serre, A. Lebleu, L. Bergeron, A. Plantivaux, J. M. Botto, C. Dal Farra, N. Domloge, Microarray profiling of gene expression in human keratinocytes suggests a new protective activity against UV-induced DNA damage for a compound previously known to interact with SCF-KIT signalling pathway. International Journal of Cosmetic Science. ,vol. 33, pp. 398- 407 ,(2011) , 10.1111/J.1468-2494.2011.00641.X
Kazuo Sutoh, Hiroshi Takatera, Hiroo Nakajima, Taisei Nomura, Kazuyasu Fukuda, Masayuki Kurooka, Li Ya Li, Takanori Kawaguchi, Eiji Taniguchi, Prakash M. Hande, Masato Ueda, Tadashi Hongyo, Induction of Cancer, Actinic Keratosis, and Specific p53 Mutations by UVB Light in Human Skin Maintained in Severe Combined Immunodeficient Mice Cancer Research. ,vol. 57, pp. 2081- 2084 ,(1997)
Thomas M. Rünger, Ulrike P. Kappes, Mechanisms of mutation formation with long‐wave ultraviolet light (UVA) Photodermatology, Photoimmunology and Photomedicine. ,vol. 24, pp. 2- 10 ,(2008) , 10.1111/J.1600-0781.2008.00319.X
Shiyong Wu, Mingjia Tan, Yuanyuan Hu, Ju-Lin Wang, Donalyn Scheuner, Randal J. Kaufman, Ultraviolet Light Activates NFκB through Translational Inhibition of IκBα Synthesis Journal of Biological Chemistry. ,vol. 279, pp. 34898- 34902 ,(2004) , 10.1074/JBC.M405616200
Zalfa A. Abdel-Malek, Douglas Smalara, George Babcock, Sungbin Im, Estela E. Medrano, Kathleen Dixon, David Mitchell, Diane Barker, Comparison of the responses of human melanocytes with different melanin contents to ultraviolet B irradiation. Cancer Research. ,vol. 55, pp. 4041- 4046 ,(1995)