Superoxide anions modulate the effects of angiotensin-(1–7) in the rostral ventrolateral medulla on cardiac sympathetic afferent reflex and sympathetic activity in rats

作者: P. Li , F. Zhang , Y.-B. Zhou , B.-P. Cui , Y. Han

DOI: 10.1016/J.NEUROSCIENCE.2012.07.048

关键词:

摘要: Abstract Both angiotensin (Ang)-(1–7) and Ang II in the rostral ventrolateral medulla (RVLM) increase renal sympathetic nerve activity (RSNA) mean arterial pressure (MAP) enhance cardiac afferent reflex (CSAR). NAD(P)H oxidase-derived superoxide anions RVLM mediate effects of on CSAR activity. However, whether Ang-(1–7) is still unclear. This study was designed to determine RVLM, including increasing RSNA MAP enhancing CSAR, oxidase major origin rats. were recorded sinoaortic-denervated cervical-vagotomized rats with urethane α-chloralose anesthesia. The evaluated by responses epicardial application capsaicin. Bilateral microinjection anion scavengers tempol or tiron, inhibitor apocynin inhibited while dismutase (SOD) diethyldithiocarbamic acid (DETC) potentiated Ang-(1–7). increased but Mas receptor antagonist D-Alanine-Ang-(1–7) (A-779) decreased level RVLM. Ang-(1–7)-induced increases abolished pre-treating A-779 not AT 1 losartan. capsaicin level; effect enhanced These results indicate that are involved modulating RVLM: CSAR. enzyme a source modulate

参考文章(48)
Rainer U. Pliquett, Irving H. Zucker, Novel mechanisms of sympatho-excitation in chronic heart failure. Heart failure monitor. ,vol. 3, pp. 2- 7 ,(2002)
Patrice G. Guyenet, James R. Haselton, Miao-Kun Sun, Chapter 7 Sympathoexcitatory neurons of the rostroventrolateral medulla and the origin of the sympathetic vasomotor tone The Central Neural Organization of Cardiovascular Control. ,vol. 81, pp. 105- 116 ,(1989) , 10.1016/S0079-6123(08)62002-6
YanFei Qi, Vinayak Shenoy, Fong Wong, Hongwei Li, Aqeela Afzal, J. Mocco, Colin Sumners, Mohan K. Raizada, Michael J. Katovich, Lentivirus-mediated overexpression of angiotensin-(1–7) attenuated ischaemia-induced cardiac pathophysiology Experimental Physiology. ,vol. 96, pp. 863- 874 ,(2011) , 10.1113/EXPPHYSIOL.2011.056994
Robson A. S. Santos, Anderson J. Ferreira, Ana Cristina Simões e Silva, Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Experimental Physiology. ,vol. 93, pp. 519- 527 ,(2008) , 10.1113/EXPPHYSIOL.2008.042002
Mei-Yan Jiang, Jun Chen, Jin Wang, Fen Xiao, Huan-Huan Zhang, Cheng-Rong Zhang, Dong-Shu Du, Yin-Xiang Cao, Lin-Lin Shen, Da-Nian Zhu, Nitric oxide modulates cardiovascular function in the rat by activating adenosine A2A receptors and inhibiting acetylcholine release in the rostral ventrolateral medulla Clinical and Experimental Pharmacology and Physiology. ,vol. 38, pp. 380- 386 ,(2011) , 10.1111/J.1440-1681.2011.05521.X
Wei Wang M.D., Ph.D., Rong Ma Ph.D., Cardiac sympathetic afferent reflexes in heart failure. Heart Failure Reviews. ,vol. 5, pp. 57- 71 ,(2000) , 10.1023/A:1009898107964
Ming-Kui Zhong, Yang-Can Duan, Ai-Dong Chen, Bo Xu, Xing-Ya Gao, Wei De, Guo-Qing Zhu, Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats Experimental Physiology. ,vol. 93, pp. 746- 753 ,(2008) , 10.1113/EXPPHYSIOL.2007.041632
Li-Min Zhou, Zhen Shi, Juan Gao, Ying Han, Ning Yuan, Xing-Ya Gao, Guo-Qing Zhu, Angiotensin-(1–7) and angiotension II in the rostral ventrolateral medulla modulate the cardiac sympathetic afferent reflex and sympathetic activity in rats Pflügers Archiv - European Journal of Physiology. ,vol. 459, pp. 681- 688 ,(2010) , 10.1007/S00424-010-0793-5
Xian-Bing Gan, Yang-Can Duan, Xiao-Qing Xiong, Peng Li, Bai-Ping Cui, Xing-Ya Gao, Guo-Qing Zhu, Inhibition of Cardiac Sympathetic Afferent Reflex and Sympathetic Activity by Baroreceptor and Vagal Afferent Inputs in Chronic Heart Failure PLoS ONE. ,vol. 6, pp. e25784- ,(2011) , 10.1371/JOURNAL.PONE.0025784
Matthew C Zimmerman, Angiotensin II and angiotensin-1-7 redox signaling in the central nervous system Current Opinion in Pharmacology. ,vol. 11, pp. 138- 143 ,(2011) , 10.1016/J.COPH.2011.01.001