作者: P. Li , F. Zhang , Y.-B. Zhou , B.-P. Cui , Y. Han
DOI: 10.1016/J.NEUROSCIENCE.2012.07.048
关键词:
摘要: Abstract Both angiotensin (Ang)-(1–7) and Ang II in the rostral ventrolateral medulla (RVLM) increase renal sympathetic nerve activity (RSNA) mean arterial pressure (MAP) enhance cardiac afferent reflex (CSAR). NAD(P)H oxidase-derived superoxide anions RVLM mediate effects of on CSAR activity. However, whether Ang-(1–7) is still unclear. This study was designed to determine RVLM, including increasing RSNA MAP enhancing CSAR, oxidase major origin rats. were recorded sinoaortic-denervated cervical-vagotomized rats with urethane α-chloralose anesthesia. The evaluated by responses epicardial application capsaicin. Bilateral microinjection anion scavengers tempol or tiron, inhibitor apocynin inhibited while dismutase (SOD) diethyldithiocarbamic acid (DETC) potentiated Ang-(1–7). increased but Mas receptor antagonist D-Alanine-Ang-(1–7) (A-779) decreased level RVLM. Ang-(1–7)-induced increases abolished pre-treating A-779 not AT 1 losartan. capsaicin level; effect enhanced These results indicate that are involved modulating RVLM: CSAR. enzyme a source modulate