Glial Response to Excitotoxic Injury in the Immature Rat Brain

摘要: Damage to the immature rat brain is often characterized by considerable anatomical reorganization and sprouting of target-depleted axons; but injury associated glial reaction, playing a potential role in plasticity, not well documented. It was classically thought that response represented negative aspect degeneration, more recent studies have pointed out participation cells production trophic factors important for central nervous system repair. This apparent neuronotrophic seems be particularly young brain, where microglial after follows rapid timecourse, leading fast removal neuronal debris, astrocytes are assumed growth supporting than adult. In our laboratory we working on an experimental model based thalamocortical connectivity order study microglia astroglial different grades affectation. this chapter describe aspects developmental injury, including interaction between these populations means cytokine factor release.