Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

作者: Christophe Guilluy , Lukas D. Osborne , Laurianne Van Landeghem , Lisa Sharek , Richard Superfine

DOI: 10.1038/NCB2927

关键词:

摘要: Burridge and colleagues demonstrate that isolated nuclei respond to force by increasing their stiffness, this mechanical adaptation is mediated emerin phosphorylation.

参考文章(34)
Brenton D. Hoffman, Carsten Grashoff, Martin A. Schwartz, Dynamic molecular processes mediate cellular mechanotransduction Nature. ,vol. 475, pp. 316- 323 ,(2011) , 10.1038/NATURE10316
Shyam B. Khatau, Ryan J. Bloom, Saumendra Bajpai, David Razafsky, Shu Zang, Anjil Giri, Pei-Hsun Wu, Jorge Marchand, Alfredo Celedon, Christopher M. Hale, Sean X. Sun, Didier Hodzic, Denis Wirtz, The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration Scientific Reports. ,vol. 2, pp. 488- 488 ,(2012) , 10.1038/SREP00488
Julia T. Philip, Kris Noel Dahl, Nuclear mechanotransduction: Response of the lamina to extracellular stress with implications in aging Journal of Biomechanics. ,vol. 41, pp. 3164- 3170 ,(2008) , 10.1016/J.JBIOMECH.2008.08.024
Yasuhiro Sawada, Masako Tamada, Benjamin J. Dubin-Thaler, Oksana Cherniavskaya, Ryuichi Sakai, Sakae Tanaka, Michael P. Sheetz, Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas Cell. ,vol. 127, pp. 1015- 1026 ,(2006) , 10.1016/J.CELL.2006.09.044
Akinori Takahashi, Yuuki Obata, Yasunori Fukumoto, Yuji Nakayama, Kousuke Kasahara, Takahisa Kuga, Yukihiro Higashiyama, Takashi Saito, Kazunari K. Yokoyama, Naoto Yamaguchi, Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization Experimental Cell Research. ,vol. 315, pp. 1117- 1141 ,(2010) , 10.1016/J.YEXCR.2009.02.010
K. E. Tifft, K. A. Bradbury, K. L. Wilson, Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases Journal of Cell Science. ,vol. 122, pp. 3780- 3790 ,(2009) , 10.1242/JCS.048397
G. W. G. Luxton, E. R. Gomes, E. S. Folker, E. Vintinner, G. G. Gundersen, Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement Science. ,vol. 329, pp. 956- 959 ,(2010) , 10.1126/SCIENCE.1189072
Wilma A. Hofmann, Primal de Lanerolle, Nuclear actin: to polymerize or not to polymerize. Journal of Cell Biology. ,vol. 172, pp. 495- 496 ,(2006) , 10.1083/JCB.200601095
J. K. Fisher, J. Cribb, K. V. Desai, L. Vicci, B. Wilde, K. Keller, R. M. Taylor, J. Haase, K. Bloom, E. Timothy O’Brien, R. Superfine, Thin-foil magnetic force system for high-numerical-aperture microscopy Review of Scientific Instruments. ,vol. 77, pp. 023702- ,(2006) , 10.1063/1.2166509