Receptor Regulation of Phosphoinositides and Calcium: A Mechanism for Thyrotropin-Releasing Hormone Action

摘要: Publisher Summary The flow of information among the cells, excluding direct electronic and mechanical coupling, involves release signal molecules into extracellular environment that bind to recognition sites on or within target cells. Numerous classes these information-bearing ligands, such as hormones neurotransmitters, serve intercellular signals. Association an informational molecule with its site initiates a cascade events transduces amplifies leading various cellular responses. Hormones neurotransmitters initiate their action at cell surface provoke rapid rise in cytosolic concentrations calcium cyclic adenosine 3',5'-monophosphate (cAMP), both. These two substances have been identified intracellular mediators hormone action. This chapter presents mechanism for thyrotropin-releasing (TRH; thyroliberin) TRH is peptide released from hypothalamic neurons binds receptor cells anterior pituitary gland. interaction induces alterations Ca 2+ homeostasis results acute thyrotropin (TSH) prolactin thyrotropic mammotropic respectively.