Gingerols and shogaols: Important nutraceutical principles from ginger

摘要: Gingerols are the major pungent compounds present in rhizomes of ginger (Zingiber officinale Roscoe) and renowned for their contribution to human health nutrition. Medicinal properties ginger, including alleviation nausea, arthritis pain, have been associated with gingerols. Gingerol analogues thermally labile easily undergo dehydration reactions form corresponding shogaols, which impart characteristic taste dried ginger. Both gingerols shogaols exhibit a host biological activities, ranging from anticancer, anti-oxidant, antimicrobial, anti-inflammatory anti-allergic various central nervous system activities. Shogaols important biomarkers used quality control many ginger-containing products, due diverse In this review, large body available knowledge on biosynthesis, chemical synthesis pharmacological as well structure-activity relationships collated, coherently summarised discussed. The manuscript highlights convincing evidence indicating that these phenolic could serve lead molecules development therapeutic agents treat life-threatening diseases, particularly cancer. Inclusion or extracts nutraceutical formulations provide valuable protection against diabetes, cardiac hepatic disorders.