Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol monophosphatases.

摘要: The enzyme myo-inositol monophosphatase (Impa) catalyzes the synthesis of free from various monophosphates in phosphatidylinositol signaling system. Impa is a lithium-blockable that has been hypothesized to be biological target for lithium-salts used as mood-stabilizing drugs treatment manic-depressive (bipolar) illness. As an initial step explore functional consequences reduced or absent activity animal model we here report isolation two Impa-encoding mouse genes, Impa1 and Impa2. spans approximately 17.5 kb contains nine exons 46--1354 bp encoding protein 277 amino acids. Impa2 at least 19.5 eight 46--444 size 290 genomic structure including positions exon-intron splice sites seems conserved among genes mammalian species. One more Impa-like do also exist evolutionary distant species like invertebrates, plants bacteria. proteins encoded by non-vertebrate seem equally related We therefore suggest duplicated common ancestral gene after divergence vertebrates.