Acute leukaemia in bcr/abl transgenic mice

摘要: The Philadelphia chromosome, widely implicated in human leukaemia, is the result of a reciprocal translocation t(9;22) (q34;q11) which abl oncogene located at 9q34 translocated to chromosome 22q11, where it fused head-to-tail with 5' exons bcr gene. In acute lymphoblastic some patients have breakpoint within major cluster region gene, whereas others break its first intron. This second type results transcription 7.0-kilobase chimaeric bcr/abl messenger RNA translated into fusion protein, p190, has an abnormal tyrosine kinase activity and strongly autophosphorylated vitro. We generated mice transgenic for p190 DNA construct find that progeny are either moribund with, or die leukaemia (myeloid lymphoid) 10-58 days after birth. finding evidence causal relationship between leukaemia.