[Omega-3: from cod-liver oil to nutrigenomics].

摘要: The leading role of cod-liver oil on rickets was a relevant factor in the knowledge this disease. In 1922 preventive and therapeutic value sunlight against young infants confirmed. seasonal variation incidence rickets, skin pigmentation, diet fact that breast milk not an adequate source vitamin D were understood. discovery essential fatty acids omega-6 omega-3 have shown deficiencies, mainly long chain polyunsaturated acids, result visual cognitive impairment disturbances mental functions also function adults, as are beneficial to vascular health may forestall cerebrovascular disease thus dementia. An ratio n-6 n-3 promote healthier balance eicosanoids, which would protect membrane with nutraceutical function. Dietary lipids only influence biophysical state cell membranes but, via direct indirect routes, they act multiple pathways including signalling, gene protein activities, modifications probably play important modulating aggregation. Significant advances been made understanding relation between dietary factors inflammation, is central component many chronic diseases, coronary artery disease, rheumatoid arthritis, cancer prevention. However, identification those who will or benefit from intervention strategies remains major obstacle. Adequate about how responses depend individual's genetic background (nutrigenetic effects), cumulative effects food components expression profiles through nutrigenomics mechanism, assist identifying responders non-responders. Thus, fish consumption might encourage brain development maintenance during aging nutrigenomic mechanism.