Exercise-induced myofibrillar disruption with sarcolemmal integrity prior to simulated diving has no effect on vascular bubble formation in rats

摘要: Decompression sickness is initiated by gas bubbles formed during decompression, and it has been generally accepted that exercise before decompression causes increased bubble formation. There are indications exercise-induced muscle injury seems to be involved. Trauma-induced skeletal vigorous could theoretically injure tissues have each shown result in profuse Based on these findings, we hypothesized prior from diving would cause increase of vascular lower survival rates after decompression. In this study, examined caused eccentric rats simulated observed the resulting Female Sprague–Dawley (n = 42) ran downhill (−16o) for 100 min a treadmill followed 90 rest 50-min saturation dive (709 kPa) pressure chamber. Muscle was evaluated immunohistochemistry qPCR, were detected ultrasonic imaging. The protocol resulted mRNA expression markers injury; αB-crystallin, NF-κB, TNF-α, myofibrillar disruption with preserved sarcolemmal integrity. Despite evident exercise, no differences amounts or exercised animals as compared non-exercised diving, novel finding may applicable humans.