Increased cortical excitability and reduced brain response propagation during attentional lapses

摘要: Abstract Modern lifestyle curtails sleep and increases nighttime work leisure activities. This has a deleterious impact on vigilance attention, exacerbating chances of committing attentional lapses, with potential dramatic outcomes. A full characterization the brain mechanisms associated lapses is still lacking. Here, we investigated signature assessed whether cortical excitability response propagation were modified during these modifications changed aging. We compared electroencephalogram (EEG) responses to transcranial magnetic stimulation (TMS) lapse no-lapse periods while performing continuous attentional/vigilance task at night, after usual bedtime. Data collected in healthy younger (N=12; 18-30 y) older individuals 50-70 both sexes. Amplitude slope first component TMS-Evoked Potential (TEP) Response Scattering (ReSc) used assess propagation, respectively. In line our predictions, TEP was characterized by larger amplitude slope. further found that ReSc over surface lower lapses. Importantly, increase decrease did not significantly differ between age groups. These results demonstrate are transient excitability, effective connectivity. pattern similar what observed sleep, suggesting reflect sleep-like phenomenon. findings could contribute develop models aimed predicting preventing real life situations. Highlights Cortical Brain reduced Aging does affect differences normal attention Lapses characteristics resemble previous reports made