Application of confocal laser scanning microscopy to differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita.
作者： Kazama , Yamamoto , Hashimoto , Komai , Ito
DOI: 10.1046/J.1365-2133.1998.02167.X
关键词:
摘要: We applied confocal laser scanning microscopy to fluorescence overlay antigen mapping (FOAM) for differential diagnosis of bullous pemphigoid (BP) and epidermolysis bullosa acquisita (EBA). FOAM tissue-bound IgG marker basement membrane components (BMCs) including integrin β4, laminin-1, laminin-5 type IV collagen, showed that in perilesional skin samples from five patients with BP was localized on the epidermal side colocalized some other three BMCs, whereas a sample patient EBA dermal all BMCs. binding sites autoantibodies patients' sera markers collagen VII 16 were collagens, above or codistributed β4 those laminin-1. These spatial relationships are compatible their previously described ultrastructural locations. Thus, this method appears be useful EBA.
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