The impact of diabetes mellitus on survival after myocardial infarction: can it be modified by drug treatment?

摘要: Aims/hypothesis. Mortality of diabetic patients after myocardial infarction remains high despite recent improvement in their management. This study population-based evaluates the impact cardiovascular drug therapy on mortality within 28 days and during 5-year follow-up compared with non-diabetic patients.¶Methods. Using MONICA Augsburg register from 1985 to 1992, 2210 inpatients incident Q-wave aged 25–74 years were included, whom 468 had diabetes. Primary end point was over 5 years. General linear model procedures used for age-adjustment, controlling sex, testing significance; hazard risk ratios calculated using multivariable Cox proportional hazards procedures.¶Results. During follow-up, 598 subjects died (396 diabetic, 202 non-diabetic). The rate 12.6 % (women 18.0 %, men 9.9 %) 7.3 (p = 0.001). increased by 64 (95 confidence interval 1.39–1.95) patients. considerably reduced 0.1).¶Conclusion/interpretation. Diabetic are at particularly dying, but benefit clearly treatment thrombolytics, beta blockers antiplatelets. does not, however, allow any inferences be drawn angiotensin converting enzyme inhibitors or left ventricular function. [Diabetologia (2000) 43: 218–226]