Prenatal and postnatal animal models of immune activation: Relevance to a range of neurodevelopmental disorders

摘要: Epidemiological evidence has established links between immune activation during the prenatal or early postnatal period and increased risk of developing a range neurodevelopment disorders in later life. Animal models have been used to great effect explore ramifications gestation neonatal A behavioral, neurochemical, molecular, structural outcome measures associated with schizophrenia, autism, cerebral palsy, epilepsy assessed activation. However, epidemiology-driven disease-first approach taken by some studies can be limiting and, despite wealth data, there is lack consensus literature as specific dose, timing, nature immunogen that results replicable reproducible changes related single disease phenotype. In this review, we highlight number similarities differences currently being investigate origins epilepsy, Parkinson's disease. describe synthesis not only but also within disease-specific models. Our inability compare equivalency dose identified significant yet easily remedied problem. We ask whether life exposure infection should described general vulnerability factor for neurodevelopmental discuss implications either classification on design, strengths limitations offuture experiments. © 2012 Wiley Periodicals, Inc. Develop Neurobiol,