Cutaneous Malignant Melanoma and Indicators of Total Accumulated Exposure to the Sun: An Analysis Separating Histogenetic Types

摘要: Evidence associating malignant melanoma with semiquantitative and questionnaire indicators of past sunlight exposure is presented from a case-control study 511 patients matched control subjects in Western Australia. That related to sun was supported by associations actinic skin damage graded cutaneous microtopography, history nonmelanotic cancer, duration residence migrants Australia, mean annual hours bright sunshine received at locations where the had resided. Separate analyses histogenetic subtypes revealed that Hutchinson's melanotic freckle strongest exposure. For superficial spreading melanoma, specific relationship observed age arrival as against Migrants arriving before 10 years appeared have risk similar native-born Australians, whereas estimated incidence those after 15 around one-quarter rate, later ages giving no additional advantage. Control Australia an increased number nevi on their arms, suggesting early life may be factor nevus production and, therefore, determinant potential develop melanoma.