V, 2.Ribosomal frameshifting in astroviruses.

摘要: This chapter reviews ribosomal frameshifting with an emphasis on the process in astroviruses. Frameshifting is a potential antiviral target. It possible that replication cycle of any virus uses this could be disrupted by modulation frameshift efficiencies, but better understanding occurrence and molecular basis will required before it can considered genuine To date, there are no confirmed examples signals from conventional eukaryotic cellular genes, although computer-assisted database searches have identified number candidates. The allows ratio viral proteins to produced, may also serve downregulate levels replicases toxic high amounts.