Uric Acid and Coronary Heart Disease Risk: Evidence for a Role of Uric Acid in the Obesity-Insulin Resistance Syndrome The Normative Aging Study

摘要: Various epidemiologic studies have linked an increase in serum uric acid level to increased risk of coronary heart disease. The reasons for this finding are unclear. authors examined the influence a number cardiovascular disease factors on 886 middle-aged and older men participating Normative Aging Study. were between 1987 1991. In multivariate regression model predicting level, was positively associated with body mass index (weight (kg)/height (m) 2 ; β = 0.041 mg/dl per kg/m , p 0.003), abdomen : hip circumference ratio (β 1.88 cm/cm, 0.048), log alcohol intake 0.150 g/week, 0.0001), postcarbohydrate insulin 0.157 log(μIU/ml), 0.005). Serum negatively age -0.012 year age, 0.017) physical activity -0.152 kcal/week, 0.0001). data suggest that may be involved obesity-insulin resistance syndrome, which turn explain relation atherosclerosis. Am J Epidemiol 1995 ;142 :288-94.