8 Enzymic Free Radical Mechanisms
作者： Edward J. Brush , John W. Kozarich
DOI: 10.1016/S1874-6047(08)60026-8
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摘要: Publisher Summary This chapter presents the enzymic free radical mechanisms of various enzymes, such as ribonucleotide reductases, monoamine oxidase, DNA photolyase, and pyruvate formate-lyase. In chapter, a general mechanistic scheme for RDPR RTPR catalysis is shown. The experimental results verification this mechanism are discussed. These strategies have involved elegant isotope effect stereochemical studies with usual nucleoside di- triphosphates. processing alternate substrates modified in 2′-position has led to discovery new mechanism-based inhibitors, whose inactivation consistent hypothesis substrate described chapter. ribonucleotide-diphosphate reductases (RDPR) ribonucleoside-5′-triphosphate (RTPR) similar despite difference cofactors respective reactions—that is, tyrosyl AdoCbl. Finally, evidence, or lack direct involvement enzyme species catalytic cycle
sci-hub.se 参考文章(219)
T.E. King, Chemical Pharmacology, H.S. Mason, Oxidases and Related Redox Systems ,(1982)
C. Paech, J.I. Salach, T.P. Singer, Suicide inactivation of monoamine oxidase by trans-phenylcyclopropylamine. Journal of Biological Chemistry. ,vol. 255, pp. 2700- 2704 ,(1980) , 10.1016/S0021-9258(19)85793-9
M. Sandler, M. B. H. Youdim, Multiple Forms of Monoamine Oxidase: Functional Significance Pharmacological Reviews. ,vol. 24, pp. 331- 348 ,(1972)
E.R. Stadtman, G. David Novelli, Fritz Lipmann, Coenzyme A function in and acetyl transfer by the phosphotransacetylase system. Journal of Biological Chemistry. ,vol. 191, pp. 365- 376 ,(1951) , 10.1016/S0021-9258(18)50986-8
Hubert. Chantrenne, Fritz. Lipmann, Coenzyme A dependence and acetyl donor function of the pyruvate-formate exchange system. Journal of Biological Chemistry. ,vol. 187, pp. 757- 767 ,(1950) , 10.1016/S0021-9258(18)56222-0
S Eriksson, B M Sjöberg, S Hahne, Ribonucleoside diphosphate reductase from Escherichia coli. An immunological assay and a novel purification from an overproducing strain lysogenic for phage lambdadnrd. Journal of Biological Chemistry. ,vol. 252, pp. 6132- 6138 ,(1977) , 10.1016/S0021-9258(17)40040-8
Gottfried Heinisch, Gerhard Lötsch, Pyridazines XXIV: Application of radicalic ethoxycarbonylation to the synthesis of pyridazine mono- and polycarboxylic acid esters Tetrahedron. ,vol. 41, pp. 1199- 1205 ,(1985) , 10.1016/S0040-4020(01)96521-4
Curtis L. Atkin, Lars Thelander, Peter Reichard, George Lang, Iron and Free Radical in Ribonucleotide Reductase EXCHANGE OF IRON AND MÖSSBAUER SPECTROSCOPY OF THE PROTEIN B2 SUBUNIT OF THE ESCHERICHIA COLI ENZYME Journal of Biological Chemistry. ,vol. 248, pp. 7464- 7472 ,(1973) , 10.1016/S0021-9258(19)43313-9
DH Dolphin, AW Johnson, R Rodrigo, N Shaw, The vitamin B12 coenzyme Pure and Applied Chemistry. ,vol. 7, pp. 539- 550 ,(1963) , 10.1021/AR50099A006
George Huntington Williams, Advances in free-radical chemistry Logos Press. ,(1965)