Fluoxetine in the Treatment of Premenstrual Dysphoria
作者： Tung-Ping Su , Peter J Schmidt , Merry A Danaceau , Marie B Tobin , Donald L Rosenstein
DOI: 10.1016/S0893-133X(96)00245-X
关键词:
摘要: We performed a double-blind, placebo-controlled, crossover trial of fluoxetine in 17 women with prospectively confirmed PMS who also met criteria for premenstrual dysphoric disorder (PMDD). A subset 10 PMDD and an additional controls participated single-dose m-chlorophenylpiperazine (m-CPP) challenge during the follicular luteal phases menstrual cycle. evaluated ability acute behavioral response to phase m-CPP administration predict therapeutic fluoxetine. Compared baseline, fluoxetine, but not placebo, treatment significantly improved both emotional physical symptoms. identified 11 (65%) responders no longer diagnostic remained symptomatic placebo treatment. In addition, improvement occurred following 7 PMDD. The small number nonresponders did respond either. Our findings confirm that is effective
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