Heavy metals bound to fine particulate matter from northern China induce season-dependent health risks: A study based on myocardial toxicity

摘要: Substantial epidemiological evidence has consistently reported that fine particulate matter (PM2.5) is associated with an increased risk of cardiovascular outcomes. PM2.5 a complex mixture extremely small particles and liquid droplets composed multiple components, there been high interest in identifying the specific health-relevant physical and/or chemical toxic constituents PM2.5. In present study, we analyzed 8 heavy metals (Cr, Ni, Cu, Cd, Pb, Zn, Mn Co) collected during four different seasons Taiyuan, typical coal-burning city northern China. Our results indicated total concentrations differed among seasons. Zn which are primarily derived from anthropogenic source, coal burning, were dominant elements, these two elements observed spring winter. To clarify whether locally health effects, conducted assessments using validated methods. Interestingly, Pb was responsible for greater potential risks to children. Because disease (CVD) main contributor mortality exposure, performed experimental assays evaluate myocardial toxicity. in vitro experiments showed metal-containing induced season-dependent apoptosis rat H9C2 cells through reactive oxygen species (ROS)-mediated inflammatory response. findings suggested bound produced by burning play important role toxicity contribute risks.