Effects of Estrogen, Raloxifene and Levormeloxifene on α1A-Adrenergic Receptor Expression
作者： Lia Banie , Guiting Lin , Hongxiu Ning , Guifang Wang , Tom F Lue
DOI: 10.1016/J.JURO.2008.07.020
关键词:
摘要: Purpose: We investigated the effect of estrogen, raloxifene and levormeloxifene on α1A-adrenergic receptor expression.Materials Methods: Postpartum rats underwent intravaginal balloon injury ovariectomy, were then treated with estrogen or placebo for 8 weeks. The urethras examined expression by Western blot analysis immunohistochemistry. Urethral smooth muscle cells isolated from untreated female receptors α β immunofluorescence microscopy. 24 hours real-time polymerase chain reaction. effects these drugs further promoter assays.Results: Estrogen treatment resulted in decreased urethras. expressed β...
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