The role of guanine nucleotides in regulation of adenylate cyclase activity.

摘要: Publisher Summary This chapter discusses the role of guanine nucleotides in regulation adenylate cyclase (AC) activity. The AC complex plays a key transfer information from extracellular first messengers such as hormones to interior cell. activated enzyme catalyzes formation second messenger—cyclic 3',5'-adenosine monophosphate—which turn regulates diverse intracellular processes. is known consist at least 3 components: hormone receptor (R), catalytic unit (C), and nucleotide-binding protein (G). reviews data on separation G clinical abnormalities involving unit. GN effects turkey erythrocyte differ certain respects mammalian receptor–cyclase systems rat reticulocyte. additionally presents cholera toxin activation AC. It describes mechanisms whereby active A1 fragment toxin—having entered cell—proceeds activate