Degree of genetic homozygosity among patients with spinal dysraphia

摘要: INTRODUCTION Our study of genetic homozygosity degree includes an analysis the presence, distribution and individual combination 15 selected genetically controlled morphophysiological traits in sample patients with spinal dysraphia (N=35) control-healthy group (N=50). OBJECTIVE Assuming that is a disease, we made hypothesis increased level, as well changed variability among patients, could be population-genetic parameter for prediction illness. METHOD Taking into consideration our experience, experience numerous scientists who studied nature inheritance mono- oligo-genically qualitative traits, applied methodology to estimate proportion such homozygously recessive characters (HRC-test,). RESULTS This did not only show statistically significant difference mean values (SD 4.8 +/- 0.3; control 3.5 0.3), but differences type too, presence certain combinations traits. CONCLUSION Due fact those genes which are distributed different human chromosomes, being their visible markers, this indicate degrees ostensibly greater compared individuals.