Identification and preliminary validation of predictors of major bleeding in hospitalized patients starting anticoagulant therapy

摘要: Among 617 hospitalized patients who started long-term anticoagulant therapy, major bleeding developed before discharge in 28 (5 percent) and minor another 38 (6 percent), with daily incidence rates of 0.4 0.5 percent, respectively. The most common site was gastrointestinal, one patient died from bleeding. Four independent risk factors for in-hospital were identified weighted using multivariate discriminant analysis a randomly chosen group 411 patients: co-morbid conditions other than the indication therapy (specific signs heart, liver, or kidney dysfunction, cancer, severe anemia); use heparin to begin age 60 years older; intensity (measured by maximal prothrombin time partial thromboplastin time); liver dysfunction that worsened during treatment. These findings validated an testing 206 patients; 151 at low (1 bleeding, 33 moderate risk, 22 high (23 risk. accuracy clinical impact this prediction rule should be evaluated further hospitals.