(+)-N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine as a discriminative stimulus in studies of 3,4-methylenedioxy-methamphetamine-like behavioral activity.

摘要: The stimulus properties of 3,4-methylenedioxymethamphetamine (MDMA)-like compounds were studied in rats trained to discriminate saline from (+)-N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine [(+)-MBDB] hydrochloride (7.18 mumol/kg; 1.75 mg/kg), the alpha-ethyl homolog MDMA. In previous experiments with (+)-MBDB as a test drug, complete substitution was observed for MDMA but not (+)-lysergic acid diethylamide or (+)-amphetamine. study reported here, cue generalized and parent 3,4-methylenedioxyamphetamine. All three drugs exhibited similar stereoselectivity, (+)-isomer having potency greater than (-)-isomer. By contrast, hallucinogens, diethylamide, 2,5-dimethoxy-4-methylamphetamine mescaline psychostimulants (+)-amphetamine (+)-methamphetamine did substitute (+)-MBDB. Cocaine produced partial substitution. results support hypothesis that primary behavioral activity MDMA-like is unlike hallucinogens stimulants may represent effects novel drug class, given name entactogens. Although mechanism action discriminative known, there evidence presynaptic serotonergic, dopaminergic, mechanisms are critical. Finally, 5,6-methylenedioxy-2-aminoindan non-neurotoxic 3,4-methylenedioxyamphetamine rigid analog previously found described here completely N-methyl derivative 5,6-methylenedioxy-2-methylminoindan results. demonstration entactogen-like properties, devoid neuronal degenerative toxicity potential, serves independent these rats.