Plasmacytoid dendritic cells promote rotavirus-induced human and murine B cell responses

摘要: B cell–dependent immunity to rotavirus, an important intestinal pathogen, plays a significant role in viral clearance and protects against reinfection. Human vitro murine vivo models of rotavirus infection were used delineate the primary plasmacytoid DCs (pDCs) initiating cell responses. pDCs necessary sufficient for activation induced by rotavirus. Type I IFN recognition cells was essential rotavirus-mediated IFN-α/β–mediated after infection. Furthermore, rotavirus-specific serum mucosal antibody responses defective mice lacking functional at time These data demonstrate that optimal virus-specific secretion following direct result pDC-derived type IFN. Importantly, shedding significantly increased pDC-deficient mice, suggesting pDC-dependent production influences clearance. Thus, critically influence course through subsequent display powerful adjuvant properties initiate enhance humoral immunity.