Etiological investigation of fatal liver failure during the course of chronic hepatitis B in southeast China.

摘要: The purpose of this study was to clarify the relationships between patients who had fatal liver failure during course chronic hepatitis B and those were also superinfected with A, C, D, or E virus, as well their virus e system status, so that suitable measures could be adopted decrease mortality B. This detected superinfections status in cases by enzyme-lined immunosorbent assay. frequency 1.4% (4/282), 6.4% (18/282), 1.8% (5/282), 28.4% (80/282), respectively, overall, 37.9% (107/282). Hepatitis prominent steady superinfection rates past 12 years. In 62.1% (175/282) patients, causes not clear. serological HBeAg(+) anti-HBe(−), HBeAg(−) anti-HBe(+) 20.6% (22/107), 23.4% (25/107), 56.1% (60/107), group 31.4% (55/175), 21.1% (37/175), 47.4% (83/175), which anti-HBe(−) more frequent clear than (P 0.05) HBeAg(−), two groups. These results suggest (107/282) is an important factor failure. can decreased strict food sanitation use safe blood products. There no significant antigen seroconversion