Differences in the terminal steps of complement lysis of normal and paroxysmal nocturnal hemoglobinuria red cells.

摘要: The number of microscopically visible lesions produced on the membrane for a given degree lysis normal cells as PNH cells. Since complement were not formed until C8 or C9 was incorporated into sequence, results suggest that increased red in is due at least part to more efficient penetration by terminal lytic sequence complement. Furthermore, efficiency when activated alternative pathway and classical analyzed. There no significant difference (p less than 0.01) lesion present an equivalent initiated antibody, cobra venom factor, acidification. Thus, does vary with different modes activation.