Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory.

摘要: The acquisition and consolidation of memories stressful events is modulated by glucocorticoids, a type corticosteroid hormone that released in high levels from the adrenal glands after exposure to event. These effects occur through activation mineralocorticoid receptors (MRs) glucocorticoid (GRs). molecular mechanisms underlie glucocorticoids on synaptic transmission, plasticity, learning memory have recently begun be identified. Glucocorticoids regulate AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate) receptor trafficking — which crucially involved transmission plasticity both rapidly persistently. Stress hormones may, modulation function, promote behaviourally relevant information.