Synthesis of isoxazolidin-5-ones via stereocontrolled Michael additions of benzylhydroxylamine to l-serine derived α,β-unsaturated esters
作者： Pedro Merino , Santiago Franco , Francisco L. Merchan , Tomas Tejero
DOI: 10.1016/S0957-4166(98)00412-1
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摘要: Abstract The synthesis of optically active isoxazolidin-5-ones from α,β-unsaturated esters is reported. key features this synthetic sequence include the stereocontrolled Michael addition benzylhydroxylamine to alkenes 7 and 8 intramolecular cyclization target compounds
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