4-aryl quinols and analogs thereof as therapeutic agents

摘要: The present invention pertains to compounds of the formula (1), which are, inter alia, antiproliferative agents, anticancer antimycobacterial antituberculosis and/or thioredoxin/thioredoxin reductase inhibitors: wherein: Q is =O or =N-S(=O)2-RQ;RQ -H optionally substituted C?1-7?alkyl, C3-20heterocyclyl, C5-20aryl; Ar R?o? an oxy substituent; bond marked α a single double bond; s R?3 and R5? are each independently ring substituents; R?2 R6? pharmaceutically acceptable salts, esters, amides, solvates, hydrates, protected forms thereof. also pharmaceutical compositions comprising such compounds, use compositions, both in vitro vivo, for example, treatment proliferative conditions, (e.g., cancer), mycobacterial infections tuberculosis), conditions mediated by reductase.