Relative risk of glucose elevation during antipsychotic exposure in a Veterans Administration population

摘要: Concern is mounting that atypical antipsychotics cause disturbance in glucose regulation ranging from reversible hyperglycemia to diabetic ketoacidosis and death. It difficult, however, know what the level of risk might be for an individual patient on a particular medication this class. We conducted retrospective nonrandomized cohort analysis measurements 18,764 patients receiving outpatient prescriptions olanzapine, risperidone, or typical 1 October 1998 30 June 2003 at six Veterans Affairs Medical Centers southeast United States. In without random plasma measurement > =160 mg/dl before exposure (n=1394), treatment with index medications was associated incidence new diabetes-level 78.7 cases per 1,000 individuals exposed year. Olanzapine greater rate developing least one =200 than risperidone (odds ratio=2.14, P=0.003). also development fasting =126 risperidone. Typical were intermediate between two atypicals. These data indicate no previously observed elevations develop during antipsychotic treatment, particularly olanzapine.