Decreased Levels of Proapoptotic Factors and Increased Key Regulators of Mitochondrial Biogenesis Constitute New Potential Beneficial Features of Long-lived Growth Hormone Receptor Gene–Disrupted Mice

摘要: Decreased somatotrophic signaling is among the most important mechanisms associated with extended longevity. Mice homozygous for targeted disruption of growth hormone (GH) receptor gene (GH knockout; GHRKO) are obese and dwarf, characterized by a reduced weight body size, undetectable levels GH receptor, high concentration serum GH, greatly plasma insulin insulin-like factor-I, remarkably long lived. Recent results suggest new features GHRKO mice that may positively affect longevity—decreased proapoptotic factors increased key regulators mitochondrial biogenesis. The alterations in biogenesis were not further improved two other potential life-extending interventions—calorie restriction visceral fat removal. This attribute primary role to resistance regulation apoptosis terms life span.