Uncatalyzed, green aza-Michael addition of amines to dimethyl maleate
作者： Giovanna Bosica , Anthony John Debono
DOI: 10.1016/J.TET.2014.06.124
关键词:
摘要: Abstract Dimethyl maleate was found to be a very reactive and selective acceptor for the aza-Michael addition in comparison other commonly used electron-deficient alkenes. It reacts efficiently with variety of aliphatic amines complete absence any catalyst solvent at room temperature. Under these environmentally-friendly conditions, high yields selectively mono-adducts were obtained within short reaction times.
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