摘要: The preparation of two acidic metabolites timolol, 2-[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yloxy]acetic acid and d,l-3-[4-(4-morpholinyi)-1,2,5-thiadiazol-3-yloxy]lactic is reported using 3-chloro-4-(4-morpholinyl)-1,2,5-thiadiazol as starting material.
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