MyProteinNet: build up-to-date protein interaction networks for organisms, tissues and user-defined contexts
作者： Omer Basha , Dvir Flom , Ruth Barshir , Ilan Smoly , Shoval Tirman
DOI: 10.1093/NAR/GKV515
关键词:
摘要: The identification of the molecular pathways active in specific contexts, such as disease states or drug responses, often requires an extensive view potential interactions between a subset proteins. This is not easily obtained: it integration context-specific protein list expression data with up-to-date that are typically spread across multiple databases. MyProteinNet web server allows users to create context-sensitive interaction networks. Users can automatically gather and consolidate from up 11 different databases generic network (interactome). They score based on reliability filter them by user-defined contexts including annotation. output includes filtered interactome files, together summary their attributes. particularly geared toward building human tissue interactomes, maintaining profiles resources. ability facilitate construction up-to-date, interactomes its applicability organisms tens tissues, make powerful tool meaningful analysis available at http://netbio.bgu.ac.il/myproteinnet.
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