Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP
作者： Jeremiah A. Johnson , Ying Y. Lu , Alan O. Burts , Yan Xia , Alec C. Durrell
DOI: 10.1021/MA1021506
关键词:
摘要: Graft-through ring-opening metathesis polymerization (ROMP) using ruthenium N-heterocyclic carbene catalysts has enabled the synthesis of bottle-brush polymers with unprecedented ease and control. Here we report first bivalent-brush polymers; these materials were prepared by graft-through ROMP drug-loaded polyethylene-glycol (PEG) based macromonomers (MMs). Anticancer drugs doxorubicin (DOX) camptothecin (CT) attached to a norbornene-alkyne-PEG MM via photocleavable linker. either or both MMs generated brush homo- co-polymers low polydispersities defined molecular weights. Release free DOX CT from was initiated exposure 365 nm light. All at least 10-fold more toxic human cancer cells after photoinitiated drug release while copolymer carrying displayed 30-fold increased toxicity upon irradiation. provides general method for systematic study structure-function relationships stimuli-responsive in biological systems.
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