Longitudinal active sampling for respiratory viral infections across age groups.

摘要: Background Respiratory viral infections are a major cause of morbidity and mortality worldwide. However, their characterization is incomplete because prevalence estimates based on syndromic surveillance data. Here, we address this shortcoming through the analysis infection rates among individuals tested regularly for respiratory infections, irrespective symptoms. Methods We carried out longitudinal sampling 214 enrolled at multiple New York City locations from fall 2016 to spring 2018. combined personal information with weekly nasal swab collection investigate 18 viruses different age groups assess risk factors associated susceptibility. Results 17.5% samples were positive viruses. Some circulated predominantly during winter, whereas others found year round. Rhinovirus coronavirus most frequently detected. Children registered highest positivity rates, adults daily contacts children experienced significantly more than counterparts without children. Conclusion widespread general population majority presenting per year. The observations identify as principal source infections. These findings motivate further active differences in pathogenicity