Genetic heterogeneity of Wuchereria bancrofti populations at spatially hierarchical levels in Pondicherry and surrounding areas, south India.

摘要: Lymphatic filariasis (LF), caused by Wuchereria bancrofti is widely distributed in areas of India with variable geoclimatic factors. These factors, coupled chemotherapeutic pressure exerted for past half a century may have influenced the genetic structure parasite populations. A complex populations will major consequences to on-going global LF elimination programme. Hence, it interest understand heterogeneity W. We studied from mf carriers residing an urban area Pondicherry and surrounding villages through molecular (RAPD) fingerprinting. The analysis showed that were mostly highly heterogeneous, while those rural homogenous. appeared be pool population originating areas. At least two genotypes, exhibiting high differentiation minimum gene flow between them, existed There was villages. adult microfilariae carrier significantly high, possibly due accumulation different genotypes increasing age. individual carrier, areas, within endemic at large, geographical regions far reaching implications epidemiology strategies chemotherapy control being adopted programme launched on scale.