New Trends Based on Experimental Results in the Treatment of Sarcoma

摘要: The enduring impasse in the success rate of conventional treatment may be overcome by a critical re-appraisal research methods and available therapeutic tools, focussing on complexity tumour microenvironment. Current do not reproduce hypoxic, acidic conditions at site nor mutual influences cancer cells with reactive fibroblasts immune cells. A peculiar feature these interactions is an increased acidity extracellular environment, this can exploited for pharmacological therapies targeting extrusion protons from cellular compartments, inducing selective cytotoxic effects cells, photodynamic approach based acid-seeking agents, extending chances conservative surgery.