How Phosphotransferase System-Related Protein Phosphorylation Regulates Carbohydrate Metabolism in Bacteria

摘要: The phosphoenolpyruvate(PEP):carbohydrate phosphotransferase system (PTS) is found only in bacteria, where it catalyzes the transport and phosphorylation of numerous monosaccharides, disaccharides, amino sugars, polyols, other sugar derivatives. To carry out its catalytic function phosphorylation, PTS uses PEP as an energy source phosphoryl donor. group usually transferred via four distinct proteins (domains) to transported bound respective membrane component(s) (EIIC EIID) PTS. organization a four-step transfer system, which all P derivatives exhibit similar (phosphorylation occurs at histidyl or cysteyl residues), surprising, single protein (or domain) coupling would be sufficient for function. A possible explanation complexity was provided by discovery that also carries regulatory functions. Depending on their state, forming cascade (EI, HPr, EIIA, EIIB) can phosphorylate interact with non-PTS thereby regulate activity. In addition, certain one components (HPr) phosphorylated ATP seryl residue, increases PTS-mediated regulation. this review, we try summarize known phosphorylation-related functions As shall see, regulation network not controls carbohydrate uptake metabolism but interferes utilization nitrogen phosphorus virulence pathogens.