Effectiveness of 2009 pandemic influenza A(H1N1) vaccines: A systematic review and meta-analysis

摘要: Background: The clinical effectiveness of monovalent influenza A(H1N1)pdm09 vaccines has not been comprehensively summarised. We undertook a systematic review and meta-analysis to assess vaccine (VE) for adjuvanted unadjuvanted vaccines. Methods: searched healthcare databases grey literature from 11 June 2009 12 November 2014. Two researchers independently assessed titles abstracts identify studies full review. Random effects meta-analyses estimated the pooled effect size vaccination compared placebo or no crude adjusted odds ratios (OR) prevent laboratory confirmed illness (LCI) related hospitalization. VE was calculated as (1-pooled OR) ∗ 100. Narrative synthesis undertaken where possible. Results: identified 9229 which 38 at moderate risk bias met protocol eligibility criteria; 23 were suitable meta-analysis. Pooled against LCI with both reached statistical significance (adjuvanted: = 80%; 95% confidence interval [CI] 59–90%; unadjuvanted: 66%; CI 47–78%); in planned secondary analyses, adults often failed reach point estimates lower than observed children. Overall hospitalization 61% (95% 14–82%); attained aged 18–64 years children Adjuvanted significantly more effective outcomes. Conclusions: preventing LCI. Overall, also influenza-related For outcomes adults.