Development of the Epidermal Barrier

摘要: After completing this article, readers should be able to: 1. Name the four epidermal strata. 2. List stratum that is primarily deficient in very low-birthweight preterm infant and its primary function. 3. Characterize physiologic similarities between developing skin lung. 4. Describe only nonectodermal cell epidermis, derivations, functions innate immune system. 5. mechanisms contributing to barrier formation. Problems related are particularly acute (VLBW) population. Approximately 500,000 infants born each year United States. (1) The survival long-term outcomes of these directly proportional their maturity weight at birth. Preterm account for 74% neonatal deaths. Those before 28 weeks gestation 50% This vulnerable population possesses an absent or incompetent barrier. (2) Such have problems with temperature control infection increased likelihood damage from adhesives superficial trauma. A better understanding ontogeny critical evidence-based guidelines care practices. Skin practices affecting VLBW include bathing/cleansing, thermoregulation, acid mantle formation, blood drawing, central venous catheters, adhesion tapes. scientific basis such grounded biochemistry development barrier. The a complex, multifunctional organ forms interface organism environment (Fig. 1⇓ ). bulk composed dermis consists collagen embedded hydrated matrix glycosaminoglycans. Blood vessels vast majority cutaneous nerve endings present dermis. cells …