Malignancies in Primary Immunodeficiencies: A Single Center Experience
作者： Turkan Patiroglu , H. Haluk Akar , Ekrem Unal , M. Akif Ozdemir , Musa Karakukcu
关键词:
摘要: Background and Aim: Primary immunodeficiencies (PIDs) are genetic disorders that predispose patients to recurrent infections, autoimmunity, malignancy. This study aimed investigate the clinical histopathological characteristics of malignancies in PIDs. Materials Methods: Herein, 11 (1 boy, 10 girls) with PIDs presented dating between 1996 2014. The were analyzed retrospectively. Results: In this 18-year period, 450 diagnosed as having PIDs, there cancer cases associated age ranged from 3 20 years a mean 10.5±6 at time diagnosis malignancies. Lymphomas observed 73% (8/11) patients. Non-Hodgkin's lymphomas (NHL) Hodgkin's (HL) seen 63% (5/8) 37% (3/8) patients, respectively. five (45%; 5/11) was diffuse large B-cell lymphoma (DLBCL), three them T-cell defects unknown etiolog...
sci-hub.se 参考文章(26)
AM Taylor, JA Metcalfe, J Thick, YF Mak, Leukemia and lymphoma in ataxia telangiectasia Blood. ,vol. 87, pp. 423- 438 ,(1996) , 10.1182/BLOOD.V87.2.423.BLOODJOURNAL872423
Daphne Morrell, Elizabeth Cromartie, Michael Swift, Mortality and Cancer Incidence in 263 Patients With Ataxia-Telangiectasia Journal of the National Cancer Institute. ,vol. 77, pp. 89- 92 ,(1986) , 10.1093/JNCI/77.1.89
Feng-Yen Li, Benjamin Chaigne-Delalande, Chrysi Kanellopoulou, Jeremiah C Davis, Helen F Matthews, Daniel C Douek, Jeffrey I Cohen, Gulbu Uzel, Helen C Su, Michael J Lenardo, None, Second messenger role for Mg2+ revealed by human T-cell immunodeficiency Nature. ,vol. 475, pp. 471- 476 ,(2011) , 10.1038/NATURE10246
Claire M Vajdic, Limin Mao, Marina T van Leeuwen, Philippa Kirkpatrick, Andrew E Grulich, Sean Riminton, None, Are antibody deficiency disorders associated with a narrower range of cancers than other forms of immunodeficiency Blood. ,vol. 116, pp. 1228- 1234 ,(2010) , 10.1182/BLOOD-2010-03-272351
Ankica Jovanovic, Predrag Minic, Marija Scekic-Guc, Slavisa Djuricic, Sanja Cirkovic, Corry Weemaes, Srdjan Pasic, Successful treatment of hodgkin lymphoma in nijmegen breakage syndrome. Journal of Pediatric Hematology Oncology. ,vol. 31, pp. 49- 52 ,(2009) , 10.1097/MPH.0B013E318190D72C
Janine K. Campbell, H. Miles Prince, Surender K. Juneja, John F. Seymour, Monica Slavin, Diffuse large cell lymphoma and t(8;22) (q24;q11) in a patient with idiopathic CD4+ T-lymphopenia. Leukemia & Lymphoma. ,vol. 41, pp. 421- 423 ,(2001) , 10.3109/10428190109057998
Bruno Fuchs, Douglas J. Pritchard, Etiology of osteosarcoma. Clinical Orthopaedics and Related Research. ,vol. 397, pp. 40- 52 ,(2002) , 10.1097/00003086-200204000-00007
Kian Eftekhari, Emil Anthony T. Say, Carol L. Shields, Roberta E. Gausas, Jerry A. Shields, Orbital lymphoma in the setting of idiopathic CD4+ lymphocytopenia (HIV-negative AIDS). Ophthalmic Plastic and Reconstructive Surgery. ,vol. 27, ,(2011) , 10.1097/IOP.0B013E31820367E1
B. Chaigne-Delalande, F.-Y. Li, G. M. O'Connor, M. J. Lukacs, P. Jiang, L. Zheng, A. Shatzer, M. Biancalana, S. Pittaluga, H. F. Matthews, T. J. Jancel, J. J. Bleesing, R. A. Marsh, T. W. Kuijpers, K. E. Nichols, C. L. Lucas, S. Nagpal, H. Mehmet, H. C. Su, J. I. Cohen, G. Uzel, M. J. Lenardo, Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D Science. ,vol. 341, pp. 186- 191 ,(2013) , 10.1126/SCIENCE.1240094
Feng-Yen Li, Benjamin Chaigne-Delalande, Helen Su, Gulbu Uzel, Helen Matthews, Michael J Lenardo, None, XMEN disease: a new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus. Blood. ,vol. 123, pp. 2148- 2152 ,(2014) , 10.1182/BLOOD-2013-11-538686