The Genomics of Escherichia coli and Beyond

摘要: The primary motivation for the switch from generating sequence data to analyzing was pace at which genomic information became available, and this chapter focuses on a few of findings that emerged comparative genomics E. coli. Based disease potential in humans, coli strains can be broadly classified as (i) harmless commensals, (ii) intestinal pathogens, (iii) those capable infecting extraintestinal sites. An active region genome evolution is mutS-rpoS intergenic region. Both mutS rpoS genes are highly conserved among strains, but between them vary 9.8 kb some enteropathogenic (EPEC) 6.9 K-12 pathogenic (ExPEC) 3.7 O157:H7 strains. polymorphism segment likely related high frequency mutations observed both rpoS. In addition substantial role gene acquisition has played formation lineages, alter or abolish protein functions have also been implicated accelerated adaptation diverse environments. most extensive study date includes 20 coli/Shigella one Escherichia fergusonii strain. summary, genomes other bacteria influenced by numerous factors, case their overall size complexity, nonadaptive processes, such mutation genetic drift, appear more important.