Oxidative stress, inflammation and cardiovascular disease in chronic renal failure.

摘要: Traditional risk factors such as hypertension, diabetes, dyslipidemia, obesity and metabolic syndrome, well additional nontraditional factors, can damage the kidney directly by promoting intrarenal atherogenesis. Evidence indicates that increased oxidative stress inflammation may mediate most of effects on kidney. Clinical studies have demonstrated a relationship between inflammatory biomarkers, few indicate an inverse correlation biomarkers with estimated glomerular filtration rate (eGFR). Further, surrogate indexes atherosclerosis intima-media thickness aortic pulse wave velocity been to be related plasma concentrations markers endothelial activation, fibrosis in patients different stages chronic disease (CKD). Moreover, high-sensitivity C-reactive protein shown left ventricular mass CKD individuals having hypertrophy. In contrast, these patients, decreases fetuin-A levels reported. Considering complex background pathophysiological changes characterizing we consider cardiovascular multifactorial complication CKD.