Aggressive pituitary tumors in the young and elderly.
作者： Christina Tatsi , Constantine A. Stratakis
DOI: 10.1007/S11154-019-09534-8
关键词:
摘要: Aggressive pituitary tumors (APTs) represent rare adenomas (PAs) with local invasion of surrounding tissues, increased risk for multiple recurrence, rapid tumor growth, or resistance to standard therapies. The most common APTs in children and adolescents are giant prolactinomas somatotropinomas. Few cases Crooke’s cell adenomas, silent corticotroph carcinomas have also been reported the literature. Pediatric patients have higher harboring germline genetic defects, commonly MEN1 AIP genes. Since certain defects confer a more aggressive behavior to PAs, testing should be considered young onset positive family history. management pediatric involves usually a combination therapies (surgical, medical, radiation). Newer agents, such as temozolomide, used few promising results. In elderly, PAs non-functioning. Their often poses dilemmas given coexistence age-related comorbidities. However, surgical treatment temozolomide seem safe well tolerated elderly patients.
springer.com
sci-hub.se 参考文章(117)
B. C. Whitelaw, D. Dworakowska, N. W. Thomas, S. Barazi, P. Riordan-Eva, A. P. King, T. Hampton, D. B. Landau, D. Lipscomb, C. R. Buchanan, J. A. Gilbert, S. J. B. Aylwin, Temozolomide in the management of dopamine agonist–resistant prolactinomas Clinical Endocrinology. ,vol. 76, pp. 877- 886 ,(2012) , 10.1111/J.1365-2265.2012.04373.X
Mônica R Gadelha, Marcello D Bronstein, Thierry Brue, Mihail Coculescu, Maria Fleseriu, Mirtha Guitelman, Vyacheslav Pronin, Gérald Raverot, Ilan Shimon, Kayo Kodama Lievre, Juergen Fleck, Mounir Aout, Alberto M Pedroncelli, Annamaria Colao, None, Pasireotide versus continued treatment with octreotide or lanreotide in patients with inadequately controlled acromegaly (PAOLA): a randomised, phase 3 trial The Lancet Diabetes & Endocrinology. ,vol. 2, pp. 875- 884 ,(2014) , 10.1016/S2213-8587(14)70169-X
Giampaolo Trivellin, Adrian F. Daly, Fabio R. Faucz, Bo Yuan, Liliya Rostomyan, Darwin O. Larco, Marie Helene Schernthaner-Reiter, Eva Szarek, Letícia F. Leal, Jean-Hubert Caberg, Emilie Castermans, Chiara Villa, Aggeliki Dimopoulos, Prashant Chittiboina, Paraskevi Xekouki, Nalini Shah, Daniel Metzger, Philippe A. Lysy, Emanuele Ferrante, Natalia Strebkova, Nadia Mazerkina, Maria Chiara Zatelli, Maya Lodish, Anelia Horvath, Rodrigo Bertollo de Alexandre, Allison D. Manning, Isaac Levy, Margaret F. Keil, Maria de la Luz Sierra, Leonor Palmeira, Wouter Coppieters, Michel Georges, Luciana A. Naves, Mauricette Jamar, Vincent Bours, T. John Wu, Catherine S. Choong, Jerome Bertherat, Philippe Chanson, Peter Kamenický, William E. Farrell, Anne Barlier, Martha Quezado, Ivana Bjelobaba, Stanko S. Stojilkovic, Jurgen Wess, Stefano Costanzi, Pengfei Liu, James R. Lupski, Albert Beckers, Constantine A. Stratakis, Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation The New England Journal of Medicine. ,vol. 371, pp. 2363- 2374 ,(2014) , 10.1056/NEJMOA1408028
Outi Vierimaa, Marianthi Georgitsi, Rainer Lehtonen, Pia Vahteristo, Antti Kokko, Anniina Raitila, Karoliina Tuppurainen, Tapani ML Ebeling, Pasi I Salmela, Ralf Paschke, Sadi Gündogdu, Ernesto De Menis, Markus J Mäkinen, Virpi Launonen, Auli Karhu, Lauri A Aaltonen, Pituitary adenoma predisposition caused by germline mutations in the AIP gene. Science. ,vol. 312, pp. 1228- 1230 ,(2006) , 10.1126/SCIENCE.1126100
Gábor L. Kovács, Miklós Góth, Fabio Rotondo, Bernd W. Scheithauer, Eivind Carlsen, Ali Saadia, Erika Hubina, László Kovács, István Szabolcs, Pál Nagy, Sándor Czirják, Zoltán Hanzély, Kálmán Kovács, Éva Horváth, Márta Korbonits, ACTH-secreting Crooke cell carcinoma of the pituitary. European Journal of Clinical Investigation. ,vol. 43, pp. 20- 26 ,(2013) , 10.1111/ECI.12010
Raj K. Shrivastava, Marc S. Arginteanu, Wesley A. King, Kalmon D. Post, Giant prolactinomas: clinical management and long-term follow up. Journal of Neurosurgery. ,vol. 97, pp. 299- 306 ,(2002) , 10.3171/JNS.2002.97.2.0299
HE Turner, CB Adams, JA Wass, Pituitary tumours in the elderly: a 20 year experience. European Journal of Endocrinology. ,vol. 140, pp. 383- 389 ,(1999) , 10.1530/EJE.0.1400383
K. Kovacs, N. Ryan, E. Horvath, W. Singer, C. Ezrin, Pituitary adenomas in old age. Journal of Gerontology. ,vol. 35, pp. 16- 22 ,(1980) , 10.1093/GERONJ/35.1.16
Samer Ghostine, Michelle S. Ghostine, Walter D. Johnson, Radiation therapy in the treatment of pituitary tumors Neurosurgical Focus. ,vol. 24, ,(2008) , 10.3171/FOC/2008/24/5/E8
Laurent Vroonen, Marie-Lise Jaffrain-Rea, Patrick Petrossians, Gianluca Tamagno, Philippe Chanson, Lucio Vilar, Françoise Borson-Chazot, Luciana A Naves, Thierry Brue, Blandine Gatta, Brigitte Delemer, Enrica Ciccarelli, Paolo Beck-Peccoz, Philippe Caron, Adrian F Daly, Albert Beckers, Prolactinomas resistant to standard doses of cabergoline: a multicenter study of 92 patients European Journal of Endocrinology. ,vol. 167, pp. 651- 662 ,(2012) , 10.1530/EJE-12-0236