Moisture-Resistant Co-Spray-Dried Netilmicin with l-Leucine as Dry Powder Inhalation for the Treatment of Respiratory Infections.
作者： Yingtong Cui , Xuejuan Zhang , Wen Wang , Zhengwei Huang , Ziyu Zhao
DOI: 10.3390/PHARMACEUTICS10040252
关键词:
摘要: Netilmicin (NTM) is one of the first-line drugs for lower respiratory tract infections (LRTI) therapy, but its nephrotoxicity and ototoxicity caused by intravenous injection restrict clinical application. Dry powder inhalation (DPI) a popular local drug delivery system that introduced as solution. Due to nature NTM hygroscopicity hinders direct use through DPI, in this study, L-leucine (LL) was added into dry reduce moisture absorption rate improve aerosolization performance. DPIs were prepared using spray-drying with different LL proportions. The particle size, density, morphology, crystallinity, water content, hygroscopicity, antibacterial activity, vitro performance, stability each formulation characterized. suitable amorphous corrugated surface. analysis indicated content decreased addition LL, whilst activity maintained. optimal ND₂ (NTM:LL = 30:1) showed high fine fraction values (85.14 ± 8.97%), which 2.78-fold those ND₀ (100% NTM). It stable after storage at 40 2 °C, 75 5% relative humidity (RH). additional DPI successfully reduced improved proved be feasible desirable approach treatment LRTI.
mdpi.com
sci-hub.se 参考文章(47)
Tomoyuki Okuda, Yumiko Suzuki, Yuko Kobayashi, Takehiko Ishii, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka, Hirokazu Okamoto, Development of Biodegradable Polycation-Based Inhalable Dry Gene Powders by Spray Freeze Drying. Pharmaceutics. ,vol. 7, pp. 233- 254 ,(2015) , 10.3390/PHARMACEUTICS7030233
Martin J Telko, Anthony J Hickey, Dry powder inhaler formulation. Respiratory Care. ,vol. 50, pp. 1209- 1227 ,(2005)
A HEALY, B MCDONALD, L TAJBER, O CORRIGAN, Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 69, pp. 1182- 1186 ,(2008) , 10.1016/J.EJPB.2008.04.020
Priya Muralidharan, Evan Mallory, Monica Malapit, Don Hayes Jr, Heidi M Mansour, Inhalable PEGylated Phospholipid Nanocarriers and PEGylated Therapeutics for Respiratory Delivery as Aerosolized Colloidal Dispersions and Dry Powder Inhalers Pharmaceutics. ,vol. 6, pp. 333- 353 ,(2014) , 10.3390/PHARMACEUTICS6020333
Qi Zhou, Thomas Gengenbach, John A. Denman, Heidi H. Yu, Jian Li, Hak Kim Chan, Synergistic Antibiotic Combination Powders of Colistin and Rifampicin Provide High Aerosolization Efficiency and Moisture Protection The AAPS Journal. ,vol. 16, pp. 37- 47 ,(2014) , 10.1208/S12248-013-9537-8
R.P. Aquino, L. Prota, G. Auriemma, A. Santoro, T. Mencherini, G. Colombo, P. Russo, Dry powder inhalers of gentamicin and leucine: formulation parameters, aerosol performance and in vitro toxicity on CuFi1 cells. International Journal of Pharmaceutics. ,vol. 426, pp. 100- 107 ,(2012) , 10.1016/J.IJPHARM.2012.01.026
A.J. Hickey, I. Gonda, W.J. Irwin, F.J.T. Fildes, Effect of hydrophobic coating on the behavior of a hygroscopic aerosol powder in an environment of controlled temperature and relative humidity Journal of Pharmaceutical Sciences. ,vol. 79, pp. 1009- 1014 ,(1990) , 10.1002/JPS.2600791113
Qi Zhou, Li Qu, Thomas Gengenbach, Ian Larson, Peter J. Stewart, David A. V. Morton, Effect of Surface Coating with Magnesium Stearate via Mechanical Dry Powder Coating Approach on the Aerosol Performance of Micronized Drug Powders from Dry Powder Inhalers Aaps Pharmscitech. ,vol. 14, pp. 38- 44 ,(2013) , 10.1208/S12249-012-9895-Z
Chiara Parlati, Paolo Colombo, Francesca Buttini, Paul M. Young, Handoko Adi, Alaina J. Ammit, Daniela Traini, Pulmonary Spray Dried Powders of Tobramycin Containing Sodium Stearate to Improve Aerosolization Efficiency Pharmaceutical Research. ,vol. 26, pp. 1084- 1092 ,(2009) , 10.1007/S11095-009-9825-2
I. Bravo-Osuna, C. Ferrero, M.R. Jiménez-Castellanos, Influence of moisture content on the mechanical properties of methyl methacrylate-starch copolymers. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 66, pp. 63- 72 ,(2007) , 10.1016/J.EJPB.2006.08.003