Cell interactions in the induction of tolerance: the role of thymic lymphocytes

摘要: Thymectomized, lethally irradiated, bone marrow reconstituted mice were treated with a large dose of sheep red blood cells (SRBC) over the course 30 days. They unable to respond further antigenic challenge for one month. Fifteen million thymocytes given 4 days after termination treatment restored their ability respond. The same similar chimeras, which differed only in having had 15 × 106 thymus added inoculum, also abolished response challenge. In contrast chimeras without present during treatment, later addition these animals did not restore response. It did, however, second antigen 17 thymocytes. This was as non-treated injection and significantly less than twice. The following explanation results is offered. Bone derived (BMD) lymphocytes that can make antibody assistance (TD) made tolerant absence TD cells. Thymus dependent BMD not. New cells, coming from marrow, broke state within month. When both populations well tolerant. regenerating abrogated population. breaking tolerance could be seen additional broken thymus. Thus, induction immunity cell populations, seems require co-operation