Hyperlipidemia in pediatric kidney transplant recipients treated with cyclosporine
作者： Blanche M. Chavers , Maria Hårdstedt , Kristen J. Gillingham
DOI: 10.1007/S00467-003-1136-Y
关键词:
摘要: Hyperlipidemia is a risk factor for cardiovascular disease in adult kidney transplant (Tx) recipients. We sought to determine the prevalence of, and factors associated with, hyperlipidemia pediatric Tx recipients on cyclosporine (CsA). identified 59 patients (mean age 8.2±5.7 years) transplanted between 1 January 1991 31 December 1993. Pre Tx, 34% had elevated total cholesterol [TC >200 mg/dl (5.17 mmol/l)]; 54% triglycerides [TG (2.26 mmol/L)]. Mean TG was higher pre dialysis (versus nondialysis) patients: 306 (3.46 mmol/l) versus 228 (2.58 (P=0.04). TC peritoneal than hemodialysis 222 (5.74 169 (4.37 (P=0.03). 3-year values correlated (TC, r=0.49, P=0.0008; TG, r=0.41, P=0.001); 3- 5-year (r=0.57, P=0.003). At 5 years post 41% of TC; 14% TG. Recipients with mean CsA concentrations at year tended receive more prednisone (P=0.06). high hyperlipidemia. The identification treatment should be included protocols.
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